DESIGNED FOR DEFENSE

A single monthly chew does the job of two or three parasiticides.

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Valid prescription required.

HIGHLY EFFECTIVE PROTECTION AGAINST HEARTWORM DISEASE

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*Studies to support FDA approval showed that one dose provided 100% protection.

FDA-APPROVED TO PREVENT LYME INFECTIONS**

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**As a direct result of killing deer ticks.

How Simparica Trio protects your dog

One prescription chew with three proven ingredients for triple protection.

Ticks

FDA-approved to
kill five types of ticks*
and blocks infections that
may cause Lyme disease.**

Heartworm disease

In studies supporting FDA approval, one dose was 100% effective in preventing heartworm disease.

Fleas

Starts killing fleas
within four hours, before
they can even lay eggs.

Roundworms and hookworms

Treats and controls roundworms and hookworms*** to protect your dog from intestinal parasites.

*Gulf Coast tick, American dog tick, deer tick, lone star tick and brown dog tick.
**As a direct result of killing deer ticks.
***For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina); (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections.

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Protection for all sizes

Safe and effective for dogs and puppies 8 weeks and older, weighing at least 2.8 lbs.

2.8–5.5 lbs.

5.6–11.0 lbs.

11.1–22.0 lbs.

22.1–44.0 lbs.

44.1–80.0 lbs.

88.1–132.0 lbs.

The Simparica Trio difference

Benefit*

Simparica Trio 

Nexgard Plus 

Heartgard Plus 

Bravecto

Credelio

Interceptor Plus 

Prevents Lyme
Infections**

Prevents Heartworm
Disease

Kills 5 Types
of Ticks

4 Types

4 Types

Kills Fleas

Treats Roundworms
and Hookworms

Approved for Dogs
8 Weeks and Older

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*Source: brand websites 10/6/2023.
**As a direct result of killing deer ticks.

The first FDA-approved product of its kind 

Simparica Trio is a tasty pork liver-flavored monthly chewable that’s convenient to administer and offers combined protection.

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IMPORTANT SAFETY INFORMATION: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.
See full Prescribing Information at simparicatrioPI.com.