My small dog ate a large dog's Simparica. Is it an emergency?
Simparica has a wide margin of safety, but Abby ingested 4 times her normal dose. You may see tremors or convulsions within the next 24 hours. These symptoms are typically self limiting and, in safety studies, resolved without treatment.
Ideally, she should be examined at the nearest veterinary ER. Vomiting can be induced via injection followed by administration of activated charcoal to further reduce absorption. This is most effective when done within an hour or two of ingestion. There is no antidote for sarolaner (the active ingredient in Simparica) overdose, so treatment is largely supportive and symptomatic until recovery is complete. This may include IV fluids and medications to control tremors or convulsions if they develop.
Updated on September 23rd, 2025