My dog is lethargic after Frontline Plus. Is this a medical concern?
Lethargy is a very general sign of illness in dogs, and can be caused by systemic illness, infection, inflammation, or injury. Lethargy isn't a side effect of Frontline, so I'm suspecting that it may be to to a medical illness. As long as Scout is eating and drinking normally as well as going to the bathroom normally, I would keep an eye on her for now. Should she still be lethargic in 48 hours, then I would be concerned and take her into the vet for an exam. If she stops eating and drinking, and develops other signs such as vomiting or diarrhea, then I would take her into a vet right away. I hope this helps!
Updated on September 23rd, 2025