My puppy got too much Trifexis for her weight. What should I do?

This medication contains a combination of Spinosad and Milbemycin. Milbemycin can be used safely in dogs for heartworm prevention but has other uses as well, and can be given at a dose two to four times the normal dose that we use for heartworm prevention, so I would not worry at all about a higher then normal dose of that medication. Spinosad is used for flea prevention and is a relatively safe drug. The most common side effects seen with its use include a decreased appetite, vomiting, diarrhea, lethargy and rarely, in dogs with a low seizure threshold, possible seizures. Studies on research dogs showed no long term effects on dogs that were given TEN times the recommended dose. Side effects that were seen at that high dose included nausea, vomiting, a decrease in appetite and some diarrhea. She will probably be OK but all you can do at this stage is monitor her for any signs of toxicity. If any are noticed she needs to see a vet immediately.

Hi there. Trifexis has a very wide margin of safety (a dog could eat an entire box and not have any serious issues, in most cases), so it's unlikely that this will cause any problems. The most likely side effect would be vomiting or GI upset, in the first day or two after taking the meds. If she's acting normal so far, you probably won't see any issues at all. It's fine for her to continue with her normal daily routine as far as eating, exercising, etc.

The age and pound limit for puppies is 8 weeks and 5 lbs. It would appear that Luna is within this range. The most common listed side effects for Trifexis include itchiness, anorexia, lethargy, redness and diarrhea. Often drugs may have other side effects that are considered uncommon and/or rare. There is also the possibility of allergic reactions to medications. If Luna appears to be in true distress to you, I would recommend getting her into a vet particularly if these side effects happened immediately after using the drug. Intervention may be required, and time is of the essence in smaller, younger patients. Hope this helps.

Toxic reactions of the main ingredient in Trifexis in dogs starts at 400mg/kg. Assuming duke had 6 tablets of 60-120lbs he had a little under 10,000 mg, for his weight toxic dose starts at 12,000 mg, so he should be safe, but if you start seeing worse symptoms or if he isn't better by tomorrow morning- take him to the vet in order to get it checked.

Poor Ember! Vomiting and lethargy are both common side effects of Trifexis, and do not usually indicate any kind of serious problem. But, you could certainly opt to use a different flea and heartworm medication for her in the future to avoid this issue. For tonight, I would withhold food and leave her alone to rest since she doesn't feel well. If she's still acting noticeably lethargic tomorrow, or if she develops any other symptoms, then I would call your veterinarian or take her in for a check-up to make sure nothing else is wrong.

Thank you for submitting your question regarding Fiona. She is unlikely vomiting from the Trifexis if she hasn't in the past. That is a small dose change for her. There are numerous causes of vomiting such as dietary indiscretion, an infection, stress or something more serious such as eating a foreign object. If she still refuses to eat or cannot keep food or water down, then she will need to see a veterinarian today. Being such a small breed dog, it is easy for her to become dehydrated. If she seems to be feeling better, give her small frequent amounts of water and food throughout the day today. I hope this information helps!

This is a very common side effect of Trifexis, if you know for sure that he didn't throw up for the first 2 hours after you gave it to him, then you do not have to treat again. the side effect will last up to 24 hours. next time try to give it a quarter tablet at a time every 15 minutes with food, this can prevent this side effect. alternatively you can switch to a different product.