My dog might have eaten an extra Trifexis pill. What should I do?

This medication contains a combination of Spinosad and Milbemycin. Milbemycin can be used safely in dogs for heartworm prevention but has other uses as well, and can be given at a dose two to four times the normal dose that we use for heartworm prevention, so I would not worry at all about a higher then normal dose of that medication. Spinosad is used for flea prevention and is a relatively safe drug. The most common side effects seen with its use include a decreased appetite, vomiting, diarrhea, lethargy and rarely, in dogs with a low seizure threshold, possible seizures. Studies on research dogs showed no long term effects on dogs that were given TEN times the recommended dose. Side effects that were seen at that high dose included nausea, vomiting, a decrease in appetite and some diarrhea. She will probably be OK but all you can do at this stage is monitor her for any signs of toxicity. If any are noticed she needs to see a vet immediately.

So this medication contains a combination of Spinosad and Milbemycin. Milbemycin is used in dogs as a heartworm prevention, and can safely be given at two to four times the normal dose used for heartworm prevention. Spinosad is used for flea prevention, and it is a relatively safe drug. The most common side effects seen with its use include a decreased appetite, diarrhea, vomiting, and lethargy. Studies on research dogs showed no long term effects on dogs that were given ten times the recommended dose. More than likely, Molly will be just fine, but if you see any of the side effects that I mentioned above, have her seen by a vet just to be safe. Best of luck, I hope this helps!

Toxic reactions of the main ingredient in Trifexis in dogs starts at 400mg/kg. Assuming duke had 6 tablets of 60-120lbs he had a little under 10,000 mg, for his weight toxic dose starts at 12,000 mg, so he should be safe, but if you start seeing worse symptoms or if he isn't better by tomorrow morning- take him to the vet in order to get it checked.

If Grace has been entirely normal since the episode of vomiting I don't think you have anything to worry about. Of course, continue to monitor for any signs of ill health like vomiting, diarrhea, lethargy, or inappetance. Thanks for using Petco Pet Education Center, formerly Petcoach and best wishes to you and Grace!

You did exactly the right thing by calling around to vets to ask for help right away. It's always best to check when you aren't sure, and are worried about your pet. The Triheart dose that we give dogs for heart worms has very small doses of the two medications that are in it. Ivermectin is one of the medications that is in the Tri heart. The dose is 68 micrograms. Veterinarians use this medication also to treat dogs with skin mites and use a dose over 100 times the dose in one heart worm preventive tablet. Therefore, even if she would have eaten two or three boxes of the Triheart she should be very safe and there is not any risk of an overdose of the ivermectin. The other medication is called pyrantel pamoate which is used for deworming of intestinal parasites. This medication has a very large safety margin also, and can be given at 10-20 times the normal dose without any risks of toxicity. Therefore, just like with the ivermectin in the Triheart Plus, I would not expect any potential side effects either. These potential side effects could include an upset stomach, mild diarrhea, and/or vomiting. Monitor her for those side effects, and bring her into your vet in the morning if you are still concerned.

Diarrhea can be a side effect of any antiparasitic medication. As long as Butter is behaving normally otherwise, you can manage it at home. Withhold food for 12-24 hours. Allow small amounts of water or unflavored PediaLyte. Resume feeding a bland diet in small, frequent amount until symptoms resolve. Begin with 1 tablespoon of food every hour and gradually increase the amount. Feed bland until the stool is normal then transition slowly to the regular diet. Symptoms to monitor for and that should be addressed by your veterinarian include lethargy, vomiting, persistent diarrhea, loss of appetite or abdominal pain.

Six hours is sufficient time for Stella to digest the Trifexis. If you didn't see the pill in the vomitus, then she digested it. Typically, another dose is recommended only if vomiting occurs within 1 hour of administration.