My dog took meloxicam, ketoconazole, Cerenia. Is this drug mix safe?

Poor K! It sounds like quite a serious periodontal issue - I hope he's feeling better soon :( Generally speaking, all of the medications you have listed are safe to be given together - none of them would be expected to have any harmful interactions. Metacam is an anti-inflammatory medication, tramadol and gabapentin are pain medications that work in different ways and are often used together, Clavaseptin and metronidazole are antibiotics that both cover different types of bacteria, and Cerenia is an anti-nausea medication that also has some anti-inflammatory effects.

The problem I see with these medications is that he is taking a steroid (prednisone) and an a non-steroidal (NSAID) - meloxicam at the same time. It is not recommended those be given together. I suggest you talk to your vet about this issue. ( https://criticalcaredvm.com/a-potentially-lethal-combination/ ) I would be worried about this as this can negatively impact the stomach, kidneys and liver. Your vet needs to decide which one he should be on (the NSAID or the steroid) and stop the other one. Divi should also be given some gastroprotectants to prevent stomach ulceration.

Ketoconazole inhibits an enzyme which is involved in the metabolism of atopica. Ideally the drugs should not be given at the same time, unless under strict supervision of your veterinarian. Hope this answer was helpful, but please do not hesitate to contact us again on the forum or by requesting a consultation if you have any more questions or to discuss it any further.

If I'm understanding her medication plan correctly, I'm a bit concerned because Metacam and prednisolone should not be given together - this combination of drugs can cause serious side effects such as stomach ulcers and internal bleeding, and I do not know of any veterinarians who would recommend giving both at the same time. I would recommend calling your vet in the morning to clarify the medication instructions, because it could be very dangerous for Peapumpkin to take both of these medications at once.

Hello, Lola is indeed at higher risk for adverse reactions even after a single dose of meloxicam, however your veterinarian is likely not too concerned with the severity of her kidney disease. Therefore, the side effects of meloxicam to her kidneys would be dependent on how severe her kidney disease is. I would recommend monitoring her kidney values for the next five days as Meloxicam has a long half-life and can take up to 5 days to remove completely from the body. This could be done with daily blood checks. Also know that of all the NSAIDs, Meloxicam has the widest safety margin in the phase of kidney disease. Look for any signs of increased drinking, decreased urinations, lethargy, painful abdomen, vomiting, or a decreased appetite and have her evaluated immediately if you note any. Hope this helps and best of luck.

Unfortunately, a well-documentive side effect of Meloxicam (and other non-steroidal anti-inflammatory drugs) is that it causes decreased blood flow to the kidneys, sometimes resulting in kidney damage. If Candy has been diagnosed with kidney problems, she definitely should no longer take Meloxicam. Your vet can discuss other alternative for pain control, including Tramadol, gabapentin, acupuncture, and physical therapy. The Azodyl can certainly be continued, but I would not give the Meloxicam, and likely she'll never be able to take it again.

As long as the smaller dog doesn't have any pre-existing liver or kidney issues, its unlikely that this will be a problem. Watch for vomiting, diarrhea, or decreased appetite, or lethargy; if you notice any of these symptoms, take him to the vet for an exam and bloodwork. Again, though, based on what you are describing, as long as Bean is otherwise healthy, I think its extremely unlikely that this will cause any issues. Thanks for asking Petco Pet Education Center, formerly Petcoach!