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Updated on September 23rd, 2025
Pet's info: Dog | Mixed Breed | Male | neutered | 9 months and 24 days old | 10 lbs
My pup had an allergic reaction to Trifexis about 2 months ago. We wanted to restart on a heart worm med so we got a RX for interceptor. Just realized some similar ingredients. Would it be safe to give him or should I stay clear of anything similar?? Also he was just neutered on 7/20 & still sore. Don’t want him to feel sick too if not necessary. Thank u!
2 Answers

Answered By Stacey Anstaett, DVM
Veterinarian
Published on July 23rd, 2018
Answered By Dr. Melanie, BVSc MS
Veterinarian
Published on July 23rd, 2018
The active ingredients in Trifexis are spinosad and milbemycin oxime. The active ingredient in Interceptor is milbemycin oxime. Milbemycin oxime is used to prevent heartworm disease, and it could be your littlest dog had a reaction to the spinosad. I would try the Interceptor, but monitor him closely for an allergic reaction. I hope this helps!
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