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Puppy on TriFexis: Need oral tick prevention. What are my options?

Updated on September 23rd, 2025

Pet's info: Dog | Labradoodle | Male | neutered | 6 months and 18 days old | 32 lbs

If I give my puppy TriFexis for the various worms and fleas, can I comebine it with anything to protect against ticks as well? TriFexis doesn’t cover ticks. I prefer an oral treatment versus topical or collars. Any recommendations? I can also swap out TriFexis but I still have 5 months worth of pills. Thank you.

1 Answer

Most Helpful Answer

Dr. Elizabeth

Answered By Dr. Elizabeth

Veterinarian

Published on January 20th, 2019

It is generally not recommended to use two oral products together. It's not to say it's impossible but many of these companies have not done the testing to know if there are interactions. You may discuss this with your regular vet to see if they have any experience with this.
Most topical flea and tick products are expected to be safe to use with Trifexis. There is also a collar called a Preventic which is fine to use with oral products. Most people only put the collar on the pet when it is going out to tick areas and they remove it when the pet is not in those areas.
Another option is to ask your vet if they would exchange the product for something like Simparica and Interceptor which would get all your parasite concerns.
Some clients will also switch products when ticks are in season or when exposure is expected and then switch back once the exposure time is over.
I hope this is helpful and please feel free to post any additional questions.
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