Is amoxicillin safe for my dog's liver and kidneys long-term?
Hi there. Amoxicillin/Clavulanic Acid is a very safe antibiotic and is not very hard on the kidneys and liver. It can cause gastric upset if given on an empty stomach, so I would recommend just giving with some food. If you see changes in urination or drinking habits you can have him checked out for his kidneys, but this medication should be fine for Danny. I would only just check out how much Danny weighs. The normal dose for Amoxicillin/Clavulanic Acid is 12.5mg/kg, so I would be giving 375mg every 12 hours to Danny assuming he weighs 30kg. Antibiotics have very large ranges in terms of dosing, and different countries will have slightly different formulations, so I would check this with your vet, as the dose may be higher with the specific compounding that your vet uses.
Updated on September 23rd, 2025