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My 50lb dog ate estradiol pills. Is it dangerous for her health?

Updated on September 23rd, 2025

Pet's info: Dog | English Springer Spaniel | Male | neutered | 50 lbs

My 50 pound dog (3 years old, otherwise healthy) ingested two of my 2 mg estradiol pills. Should I be concerned? I was told to post with more detail because the concentration of the pills is important, but I'm not sure what that means in this context. The medication code is NDC 0378-1458-77 if that is helpful.

1 Answer

Most Helpful Answer

Daniela Jessen, DVM

Answered By Daniela Jessen, DVM

Veterinarian

Published on December 27th, 2018

Hi,
The levels of concern for estrogen are dosages > 1mg/kg.
In this case as I can understand from your question the dog ingested 2 tablets of 2 mg estradiol which is a total of 4 mg estradiol. If we devide the 4 mg by the dog weight 25 kg we get a dose of 0.16 mg/kg ingested which is much lower level than 1 mg/kg. So if these are the right details it is not at the toxic range (of bone marrow suppression). Just keep it in cupboard or a drawer away from Loli.
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