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Does Zylkene for dog anxiety cause tolerance or work right away?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed | Female | 6 years old | 11 lbs

My vet just prescribed medication called zylkene 225mg for some stress and anxiety issues I was told this could be taken daily or as needed. If taken daily will she eventually build up a tolerance to this medicine And if so will it be less effective over time? Or if given as needed does it work right away or take a few days to build up in her system? Thank you for your time

1 Answer

Most Helpful Answer

Linda G,  MS, DVM

Answered By Linda G, MS, DVM

Veterinarian

Published on September 23rd, 2019

Hello. Zylkene is a supplement that is generally used in pets with mild chronic anxieties. In general, I can find no reference to a tolerance building up in pets that use this long term ( months ), so you should keep a written diary of how your dog behaves on the Zylkene & if using it daily seems to calm her anxieties. If you think it is of some benefit, especially after 1-2 weeks of daily use, then I would continue it daily for an additional 2-4 weeks. Then, try her on every other day. Supplements are a trial & error & generally will not work as well as a prescription anxiolytic will work. So try it daily & do not worry about Kiwi building up a tolerance. Thanks for using Petco Pet Education Center, formerly Petcoach.
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