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Does nursing puppies after their first shots make them ineffective?

Updated on September 23rd, 2025

Pet's info: Dog | Beagle | Male | unneutered | 1 month and 15 days old | 5 lbs

I’ve been told that after puppies have their first needle letting them feed from the mother will cancel out the purpose of the needle – is this true?

1 Answer

Most Helpful Answer

Sara Farmer, DVM

Answered By Sara Farmer, DVM

Veterinarian

Published on August 5th, 2017

It is true that maternal antibodies can interfere with the immune system's ability to respond to a vaccine in a young puppy, but puppies do not get significant antibody from the mother's milk past the first day so it is absolutely fine for them to continue to nurse. One reason we give so many vaccine boosters when puppies are young is because it is difficult to predict exactly when mom's antibody will start to decline in the puppy so that they can mount their own adequate immune response. Usually maternal antibody is completely gone sometime between 16-20 weeks, which is why we try to time the last vaccine booster around then.
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