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Updated on September 23rd, 2025
Pet's info: Dog | Bichon Frise | Male | unneutered | 12 lbs
My dog has very high liver enzymes 224 alt and 1976 alkp. These are down from>2000 and 296 after denamarin twice a day. We are now adding ursodiol 1/2 250 mg pill twice a day. At 15 pounds this seems higher than the recommeded doses I have read. Your Thoughts?
2 Answers

Answered By Linda G, MS, DVM
Veterinarian
Published on March 5th, 2020
Answered By Linda G, MS, DVM
Veterinarian
Published on August 12th, 2020
Hello. I am so sorry that Molley has such liver disease. Normally we would administer ursodiol at 10-15 mg/kg. This would be approximately 118-177mg every 12 hours. But this is a very safe medication with a very low level of toxicity. You can speak with your veterinarian about this, but it is not an outlandish or worrisome dose. I would certainly see how she does on the 30 days & if she should develop any complications like diarrhea or constipation, then you may need to cut back. Thanks for contacting Petco Pet Education Center, formerly Petcoach.
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