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Can I give Trifexis to my spayed dog on Amoxi/Clav and Carprofen?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Female | 7 months and 24 days old | 33 lbs

My dog was just spayed and developed an infection. She's taking Amoxi/Clav for the infection and Carprofen for pain and inflammation. I just realized her Trifexis is due today and the vet's office is closed. Is it safe to give her the Trifexis along with these two other medications?

1 Answer

Most Helpful Answer

Jennifer Summerfield, DVM CPDT-KA

Answered By Jennifer Summerfield, DVM CPDT-KA

Veterinarian, Certified Dog Trainer

Published on March 25th, 2021

Hi there. Yes, that should be okay - Trifexis doesn't have any harmful interactions with those meds. The only possible issue I can see is that all three of them have stomach upset as a potential side effect, so if your girl has a sensitive stomach or has a history of vomiting when you give the Trifexis, then it may be better to wait until she's finished with her current meds to give it. But if not, it should be fine to go ahead and give it today if you want to. :)
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