Petco Text Logo
Petco Pet Logo
  • Two Easy Ways to Start Earning Rewards!

    rewards header
    Become a member today!
    Members-only pricing and offers, personalized care notifications, Vital Care points back on every purchase and more!
    Petco Pay LogoBecome a credit card member today!

    Earn 2X Pals Rewards points at Petco
    when you use Petco Pay!

    APPLY NOW
    Learn More About Petco Pay Benefits

My dog's seizures returned on zonisamide. Should I up her dose?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Female | unspayed | 38 lbs

My dog started having seizures back in May. She since has been put on zonisamide twice a day to control her seizures. She went 6 weeks without having one since she was first put on zonisamide and had 3 today. Thinking she may have epilepsy. Would epilepsy prevail over the zonisamide? The vet sent her home with instructions to up her dosage of zonisamide. She is also diabetic and takes insulin but her levels were normal after the seizures. Any input?

2 Answers

Most Helpful Answer

Dr. Melanie, BVSc MS

Answered By Dr. Melanie, BVSc MS

Veterinarian

Published on September 18th, 2019

Sometimes the anti-seizure medication needs to be increased to control the seizures, there is a chance they could get worse over time as you've seen. I think upping Mali's dosage is a good idea, and see how this helps her. If it doesn't, take her back into the vet.
Vote Icon1Pet Parents found this answer helpful

Related Answers from Veterinarians

  • Answered By Ann Dion, DVM

    Veterinarian

    Published on April 1st, 2017

    Hello. I am sorry that Bayleigh isn't feeling well. Decreasing any seizure medication can result in a seizure, and is never recommended without direct veterinary supervision. If you feel that the Zonisamide is resulting in negative side effects, chat with your vet about switching to either Pexion or Phenobarbital or Keppra. These are newer medications that may have less side effects for Bayleigh. Depending on her levels and the medications, your vet will tell you how to switch safely. Good luck with her!

    Vote Icon

    1Pet Parents found this answer helpful

Smart Picks for Smart Questions

Have A Vet Question?

Book an appointment with the pros – our expert vets are here to help.

Share

Styled arrow button