Is it safe to give my high-energy dog gabapentin and trazodone?

Thank you for contacting Petco Pet Education Center, formerly Petcoach with your question about Duke. I'm sorry that he's been struggling lately, how hard for him and you. You can use the gabapentin and trazadone together. Yes, they can cause increased sedation together, but that may be a good thing if he's sundowning. It will help him sleep and keep him on a regular schedule. I hope this helps!

Yes you can give it with the other medications. Personally I’d not give Nico the gabapentin when giving the trazodone just to be extra cautious since you’ll only be giving it one night for the fireworks. Thanks for using Petco Pet Education Center, formerly Petcoach to help you get answers to your veterinary questions.

It is safe to give these medications together and they are often prescribed for sedation. The sedation typically lasts 12-24 hours. You could ask your vet about trying the medications before you travel to make sure the level of sedation seems appropriate; that way you could discuss a dose adjustment with your vet if needed.

Hello. Most times you can give Anipryl along with Trazodone safely. On occasion, if the doses were/are high enough with both drugs, you might see serotonin syndrome. I am sure your veterinarian is quite aware of the doses used & is confident that Mitch will be fine. If you do see any unusual symptoms, agitation, muscle stiffness, distress, pacing, call your veterinarian. This is easily treated. Thanks for using Petco Pet Education Center, formerly Petcoach.

Hello, thank you for using Petco Pet Education Center, formerly Petcoach. While I usually use either gabapentin or tramadol, either one can be safely used with the prednisone. But tramadol can be used in conjunction with the gabapentin and a non steroidal anti-inflammatory medication ( or pred ) for chronic pain conditions. Take care.

I cannot find any interaction reports for Trazodone with carprofen (Rimadyl), however there are reports that Trazodone has interactions with Ibuprofen, a similar class of NSAID. This reports that either increases toxicity of the other by added drug effects. Check with your veterinarian on whether he recommends giving the two together. There maybe less toxic effect by giving the Rimadyl in the morning and the Trazodone in the evening. However this is for your vet to decide. If you cannot reach your veterinarian I suggest not to give the Trazodone tonight and keep the dog in a room where she is not likely to be bothered much by trick or treaters.

There is no problem with combining isoxazoline medication like Credelio with trazodone. It should be fine to give the trazodone as prescribed. Potential side effects of both medication include diarrhea and a decrease in appetite, but if you have given both medications before without a problem you’re unlikely to see this problem now.