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Updated on September 23rd, 2025
Pet's info: Dog | Labrador Retriever | Male | neutered | 70 lbs
My dog stopped taking Anipryl 4 days ago. Now my vet wants me to give him trazodone tonight to try to treat his canine cognitive dementia. Everything I have read said to wait 2 weeks but she says that is not necessary. What is your opinion ? I am afraid of serotonin syndrome.
2 Answers

Answered By Linda G, MS, DVM
Veterinarian
Published on January 30th, 2020
Answered By Jennifer Summerfield, DVM CPDT-KA
Veterinarian, Certified Dog Trainer
Published on January 26th, 2020
The safest bet is to allow a washout period of about two weeks before starting a new medication that affects serotonin levels, such as tramadol or trazodone. However, in some cases the new medication can be started sooner if the need is urgent, under close supervision by your veterinarian. I would recommend talking to your regular vet about this if you are concerned that your dog needs to start the new meds ASAP.
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