Why is my senior cat sick, vomiting, and weak with normal bloodwork?

Poor Checker! This is a huge amount of weight to have lost in a year, so I would say that something is definitely wrong. In older cats with significant weight loss like this and normal blood work, the most common possible causes would be an intestinal absorption issue like inflammatory bowel disease (which can be present even if she is not having diarrhea), or some type of abdominal cancer. The next diagnostic steps would be abdominal x-rays and ultrasound, with exploratory surgery and intestinal biopsies if needed to get a definite diagnosis. If this isn't possible for financial reasons, a trial course of oral steroids and injectable vitamin B12 might be helpful - I would suggest discussing these options with your vet to see what he/she recommends.

Persistent vomiting and refusal to eat is concerning, especially in an elderly pet where they may be weight loss or dehydration. Given the clear blood work i would be concerned about a possible obstruction, hairballs, tumours or a twisted bowel are all possible. Xrays may be recommended as well as tube feeding to maintain calorie intake until a diagnosis has been reached

Poor Sachi! Significant weight loss and inappetence are certainly a major concern. I'm glad to hear that his blood work (I assume a CBC, chemistry and T4?) was unremarkable. However, foreign body intestinal obstruction/blockages, intestinal malabsorption issues that can cause inflammatory bowel disease (IBD) or exocrine pancreatic insufficiency (EPI), chronic pancreatitis, or cancerous processes, do not necessarily cause changes on screening blood tests. If Sachi has not yet had abdominal x-rays or an ultrasound, consider talking to your vet about these tests as his next diagnostic step. If he has a foreign body obstructing his intestines, this is a surgical emergency, and these tests would be helpful in obtaining a diagnosis. If pancreatitis, IBD or EPI are more highly suspected, consider talking to your vet about testing for vitamins B12 and folate, as well as TLI and fPLI. I hope this helps!

I'm so sorry you're dealing with this. It sounds like your kitty is very ill. I would recommend taking him to an emergency clinic (or his regular clinic tomorrow if an emergency clinic is not possible) for an exam and labwork. This could be something treatable (or at least manageable, if not curable) or it may not be. I would be worried about kidney disease, thyroid disease, diabetes, cancer, and liver disease - it could definitely be other things too, but these are at the top of my list. Good luck with your kitty. Let me know if this was helpful advice or setup a consultation if you need further help.

Hi there and thank you for using Petco Pet Education Center, formerly Petcoach to address your concern. If Willow did not have her blood tested when she was in for her exam I would highly recommend having the vet pull a blood sample and check to see if she has any abnormal values. Kidney disease is something we quite commonly see in older cats and this certainly could be the cause of the vomiting / decreased appetite. The sooner her blood is tested the better and the faster you will know what is going on with her. I hope this helps guide you in the right direction. Please let me know if you have any other questions or concerns and I would be more than happy to help you further.

Elvis' signs of weight loss, vomiting and seizure activity are highly concerning. I'm glad that his blood testing was normal, but in an older cat that is experiencing seizures, a brain tumor is a major concern and will not typically cause any changes on blood testing. An MRI scan is needed for this diagnosis. Normal blood work rules out common causes of weight loss in an older cat, such as kidney disease and hyperthyroidism, but as I mentioned, there is not a specific test for all cancers. Elvis needs to see his vet immediately because his twitching and balance issues could be a result of focal seizures rather than the grand mal seizures to which you are likely accustomed to seeing. Your vet will be able to discuss any recommended diagnostics and treatment options.

It's interesting that her blood work was normal with that information. If she is losing weight and urinating a lot, it is possible that she could be losing protein in her urine. A urinalysis would check for this. Hyperthyroidism is another cause for weight loss in an older cat. Thyroid hormones are easily tested for but not commonly found on routine lab work - it has to be specifically requested. Another possible cause for the inappropriate urination and defecation in a senior-aged kitty would be pain from arthritis. It sounds like your vet hasn't quite gotten to the bottom of Olivia's medical concerns. I would take her back in for follow-up so they can move on to the next step in diagnostics. Also, we can never completely rule out cancer, since there is no simple cancer test. It can be a little tricky to find if the body isn't showing us specifically where it could be, but I am hoping that isn't what is going on in this case.