Why is my cat weak, losing weight, and not eating after normal blood tests?

It sounds as though you and Schumacher have been through a lot over the past 2 years! Given his weight loss, chronic diarrhea, normal blood work and initial response to depomedrol, chronic pancreatitis or primary intestinal issues, such as inflammatory bowel disease or lymphoma would be my main concerns. In this situation, further diagnostic testing is often needed to try to get to the bottom of this issue. Some tests include vitamin absorption and pancreatic blood tests (B12, folate, TLI, fPL) and an abdominal ultrasound to look at his internal organs, intestinal thickness, lymph nodes, etc. In some cases, biopsies are needed to differentiate between different conditions so that the most appropriate treatment can be started. Cats with inflammatory bowel disease or lymphoma often benefit from long-term steroids, antibiotics and prescription diets to control their clinical signs. I hope that all goes well for Schumacher!

HI, thanks for using Petco Pet Education Center, formerly Petcoach! Poor Newton! Wow, you have done a lot and I am surprised you haven't found an answer. I would be sure fecal testing has been done and feline leukemia/FIV testing, chest X-rays, B12/folate/TLI/PLI testing then I would take him to surgery to explore his abdominal cavity and I would biopsy everything. Looking for lymphoma. He should have a feeding tube (esophageal) placed a surgery so he can be fed while you wait for biopsy results. Also if it has been more than 1 month since the CBC/Chemistry has been ran I would repeat it. I wish you the best

If all his bloodwork was normal that rules out kidney disease, liver disease, diabetes, etc. If your vet did not test for hyperthyroidism than a test should be done. An x-ray and/or ultrasound is defintely needed and will, hopefully, provide more information. He could have an infection, cancer, or obstruction/foreign body to name a few other possibilities. If he is not able to keep food down, I am not sure waiting until Friday is a good idea. He may continue to weaken and may become dehydrated. If your vet can't take an x-ray then you could consider taking him to an emergency clinic or another vet that can. An anti-vomiting injection may be helpfull if your vet didn't give him one. I hope that his problem is diagnosed and treated soon!

I agree with your concerns - not eating for 5 days is certainly not normal. I'm glad to hear that Bentley's blood work was overall normal, but I am curious as to whether or not he was tested for fPL, which is a test to raise or lower suspicion of feline pancreatitis. Possible causes of his sudden loss of appetite not apparent on routine lab testing include pancreatitis, inflammatory bowel disease, cancer, intestinal obstruction (I would expect more vomiting, however), among others. The main concern, particularly since Bentley is such a big cat, is that he could develop hepatic lipidosis (fatty liver disease) as a result of not eating for this length of time, which can be quite severe. If Bentley is still not eating by tomorrow morning, I strongly recommend taking him back to the vet to discuss further testing, such as the fPL blood test or abdominal ultrasound to get to the bottom of this issue. I hope that he is on the mend soon!

Poor Checker! This is a huge amount of weight to have lost in a year, so I would say that something is definitely wrong. In older cats with significant weight loss like this and normal blood work, the most common possible causes would be an intestinal absorption issue like inflammatory bowel disease (which can be present even if she is not having diarrhea), or some type of abdominal cancer. The next diagnostic steps would be abdominal x-rays and ultrasound, with exploratory surgery and intestinal biopsies if needed to get a definite diagnosis. If this isn't possible for financial reasons, a trial course of oral steroids and injectable vitamin B12 might be helpful - I would suggest discussing these options with your vet to see what he/she recommends.

Hi there and thank you for using Petco Pet Education Center, formerly Petcoach to address your concern. Based on these lab results, I would suspect renal disease. BUN, Amylase, magnesium and CPK all can become altered with renal impairment. The weight loss may be due to muscle wastage due to chronic renal disease or something else may be going on. I would consider having Tigger's urine specific gravity checked and also send out an SDMA test to see if the kidney's are the main problem. At 14.5 years of age, renal disease would be high on my list of causes of these symptoms. Other problems such as cancer and inflammatory diseases may be the cause of the symptoms as well. I would recommend having your vet pursue additional testing to get more of a definitive answer on whether or not the kidneys are impaired and if not, coming up with further recommendations on diagnostics and treatment. I hope this helps guide you in the right direction. Please let me know if you have any other questions or concerns and I would be more than happy to help you further.

Thank you for submitting your question regarding Poutcha. His blood work appears fairly unremarkable. His blood sugar is a bit high, but his fructosamine level is normal. Is he diabetic or was this just a screening test? Since he is not improving, I recommend a urine sample be tested and bloodwork for pancreatitis. X-rays of his chest to look for cancer are always a good idea as well. Based on these results, additional bloodwork or even an abdominal ultrasound by a radiologist might be warranted. I hope this information helps!