Cat ear infection with odor/drainage: why aren't antibiotics working?

I would recommend taking grandma kitty back to the vet if you are getting this much discharge still. It appears the medication they gave you is an ear cleaner with an antifungal in it. It is possible she needs stronger antibiotic drops. Typically animals do not need oral antibiotics for outer ear infections just topical. I also would request they check for ear mites to make sure none are seen. Hope that helps

Ear mites and underlying allergic disease (that can predispose to recurrent ear infections) are possible and should be ruled out. A physical and otoscopic examination of the ear canal are enough to rule them out. Bacterial swabs and culture can be used as well to rule out resistant infections. I would recommend to discuss all these options with your veterinarian. Please do not hesitate to contact us again on the forum or by requesting a consultation (where you can post pictures ) if you have any more questions or to discuss it any further.

Although you aren’t seeing any improvement yet, continue giving the medication as previously prescribed. Sometimes it can take 2 weeks to get the infection under control. Keep in mind also that the infection may be getting better but there is still some exudate/debris in the ear. If, by the time you return from your trip, there is still no improvement, make an appointment for a recheck examination with your vet. Occasionally there are resistant infections that need special medication. Hopefully this will not be the case for Lulu. Also, if it makes you feel better, judging by the picture you provided Lulu’s ear looks pretty good! I hope the helps. Thanks for using Petco Pet Education Center, formerly Petcoach. Best of luck.

If the antibiotics are helping, it's probably a middle ear infection indeed. a sample needs to be taken from the ear and sent for culture and sensitivity, then the best antibiotic can be chosen according to the result. the course of treatment must be longer next time, at least 4 weeks as these infections take a long time to resolve.

Thanks for using Petco Pet Education Center, formerly Petcoach! The medication has an antibiotic and an antifungal in it. If it didn’t help the infection, she may have a bacteria that is resistant to the antibiotic. I recommend taking her back to the vet for a culture of the bacteria in her ear to determine what medication will treat it. Good luck and kisses to Bailey!

If the infection goes that far, we often use antibiotics tablets (sometimes two different types at the same time, as Melcho is having now) and strong anti-inflammatory medications, usually steroids. You should get in touch with your vets again, as it sounds that your Melcho is struggling at the moment and he may benefit from more aggressive therapy.

The discharge inside the ear needs to be cultured so you can know what is growing in the ear canal - what bacteria, yeast, etc. That way the vet will know what medication to use to get it to clear up. The ear may also need to flushed out under anesthesia. There must be an underlying cause. Cats typically don't get ear infections chronically like dogs. It is not likely to be a food allergy. More testing needs to be done.