Your guinea pig may have an upper respiratory infection or a tooth abscess. You should take it to a veterinarian familiar with guinea pigs for a check up of his teeth (guinea pigs often have malocclusions and teeth that are too long). If there is an upper respiratory infection your cavy needs to be treated with injectable antibiotics. Guinea pigs cannot take antibiotics by mouth as it kills their intestinal flora and can indeed kill the guinea pig. Should the crusts go away and your guinea pig eats and drinks well and is happy, then this might have been caused by a draft and it will not need a vet visit.