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Puppy lepto vaccine reaction within 24 hours? What should I do?

Updated on September 23rd, 2025

Pet's info: Dog | Yorkshire Terrier | Female | spayed | 3 months and 13 days old

If a side effect occurs within my puppy within 24 hrs after the leptospirosis vaccine, what's the best thing to do for her & give her?

1 Answer

Most Helpful Answer

Destini R. Holloway, DVM

Answered By Destini R. Holloway, DVM

Veterinarian

Published on November 16th, 2016

Well that depends on the severity of the adverse reaction. If she is having a mild vaccine reaction (1 bout of vomiting, loose stool), then an anti-histamine (i.e. Benadryl) can be given in most cases and will calm the reaction down. However if she is having a more severe adverse reaction (i.e. continuous vomiting, anaphylaxis, severe lethargy, anorexia), then she will need an antihistamine shot (for immediate reversal), +/- steroid shot from your vet , +/- fluid therapy and close monitoring to ensure that the reaction subsides and that she remains stable.
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