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Is it safe to give my pet metronidazole with phenobarbital?

Updated on September 23rd, 2025

Pet's info: Dog | American Foxhound | Male | neutered | 5 years and 6 months old | 83 lbs

Does metronidazole and phenobarbital have any concerning interactions?

1 Answer

Most Helpful Answer

Dr. Melanie, BVSc MS

Answered By Dr. Melanie, BVSc MS

Veterinarian

Published on December 27th, 2016

Phenobarbital speeds up liver activity, which can have an affect on drugs that are metabolized by the liver, such as metronidazole. That means that it may be metabolized more rapidly, requiring an adjustment in the dose of metronidazole. I would speak to your vet about this interaction.
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