My puppy is lethargic and in pain after vaccinations. Is this normal?
I'm sorry to hear that Lettie is not feeling like her usual self! It should be noted that even normal puppy vaccines can lead to some side effects such as lethargy (decreased activity, tiredness), swelling or tenderness around the injection site and even mild nausea (possibly the drooling). That being said, rarely dogs can undergo an allergic reaction to vaccines which often show up as vomiting, collapse, and swelling of the face or other limbs. If these have been observed she should be seen by a veterinarian immediately.
In regards to the safety of administering the Heartguard and Nexgard along with the vaccines, it is standard protocol to begin these preventative medications at this time and are safe to give to a puppy of Lettie's age.
The most important thing going forward is to continue to monitor Lettie for any worsening or changing of her clinical signs. For example, if she starts to vomit becomes even more tired or lethargic, continues to want to eat or do anything after more than a day, or even have swelling around her face then she needs to be seen by a veterinarian immediately.
Updated on September 23rd, 2025