My dog ate PROIN. Is it toxic? What symptoms should I expect?
Proin starts to be toxic at about 15mg/kg. Kobi ingested just over 6.8mg/kg and at that dose the most common side effects are mild hypertension (high blood pressure) and bradycardia (slow heart rate). Of course, every dog is different. I suggest you have Koji examined by your veterinarian especially if you are noticing any abnormal behavior.
Other adverse effects can potentially be seen even at therapeutic doses. They include restlessness, urine retention, anorexia (not wanting to eat), tachycardia (increased heart rate), and hypertension (high blood pressure). Stroke-like signs have been reported rarely. Other rare clinical manifestations of toxicosis may include piloerection (hairs standing up on end), vomiting, tachypnea (fast breathing), anxiety or agitation, hyperthermia (increased body temperature), tachycardia, tremors, and potential seizures.
Updated on September 23rd, 2025