My dog has an itchy skin lump that won't go away. How can I help?

I would recommend taking Alfie to the vet to have the lump looked at. A wart can become infection however warts are not very common in younger dogs. It is possible Alfie has a skin infection, cyst, non cancerous growth or even an allergic reaction. You can try an over the counter anti histamine but a vet visit would be the best option

This could just be a bite or spot that has caused a bit of allergic reaction in the skin. If it is an area of allergy or infection it will resolve with time. If it doesn't go away it is a mass in the skin, such tumours can be benign or cancerous but need to be tested to know.

It is hard to tell from the picture but it maybe the start of a pustule which can be a sign of a skin infection. It may also be a cyst or sebaceous adenoma or wart as they have a similar looking characteristic. Since she has been through Cytopoint and Apoquel with out much relief, she may benefit from a dermatologist to get intradermal allergy testing. Your vet can check that spot to be sure what it is and set up a referral for the skin if you wish to pursue that route

That could be a little cyst or tumor or a black head (pimple) If your dog keeps scratching it, you should have it examined by a vet who can evacuate it in such a manner that it does not get infected, If it is a little tumor that keeps bothering him, it will be better to have it removed.

I doesn't look like an insect bite. It could be a small wart or other mass. The only way to know for sure would be to have it examined by a vet and have a sample evaluated under the microscope. There is a type of tumor called a Mast Cell Tumor that can cause itching.

According to the picture this looks like a wart that Lady scratched and now has a scab on it. Since she is bothering with it and seems uncomfortable I would take her to see your veterinarian. They can make sure it is nothing else like a scratch that got infected or a different type of growth that go infected and scabbed over. They also will be able to give her a topical ointment to place on the area to help with any type of infection. If this is something that continues to bother her or scab over I would recommend removing it so it does not continually get infected and bother her. If she is scratching at it I would put an e-collar on her so she does not make it worse. As dogs age it is very common for them to get more warts like these, some may bother them while others will not.

It looks like her skin is just very inflamed in that area from all the scratching. I suggest you take her to your vet for an exam. She will likely need some strong prescription medications to get this to clear up. In the meantime you can use this hydrocortisone spray on it to give her some relief: ( https://www.petco.com/shop/en/petcostore/product/zymox-spray-with-5-hydrocortisone ) Hope this helps. Best wishes.