Is it safe to give my dog human hydroxyzine for separation anxiety?
Thank you for using Petco Pet Education Center, formerly Petcoach! While hydroxyzine is an antihistamine commonly used for allergies and might cause mild sedation in dogs, it is unlikely to resolve Hunter’s separation anxiety. I recommend trying positive reinforcement, providing distractions, or even using calming supplements for dogs or a product known as a “thundershirt” prior to resorting to medications. You should consult with your vet regarding any medications you may want to give to Hunter to confirm that there will be no interactions with anything he is currently taking and that the dose is appropriate for his size.
Updated on September 23rd, 2025