Petco Text Logo
Petco Pet Logo
  • Two Easy Ways to Start Earning Rewards!

    rewards header
    Become a member today!
    Members-only pricing and offers, personalized care notifications, Vital Care points back on every purchase and more!
    Petco Pay LogoBecome a credit card member today!

    Earn 2X Pals Rewards points at Petco
    when you use Petco Pay!

    APPLY NOW
    Learn More About Petco Pay Benefits

My dog is sick from heartworm medicine. Are these side effects normal?

Updated on September 23rd, 2025

Pet's info: Dog | Saint Bernard | Male | unneutered | 10 months and 26 days old | 100 lbs

Cooper has not eaten in 4 days. He is vomiting, very lethargic and just not himself. He had shots last week and was tested positive for Lyme. Taking doxycycline for that. He was also given Milbeguard heartworm preventative. The side effects from the heartworm medication is spot on with what is going on with him. We contacted our vet office and they said it sounds normal. I am just curious how long these adverse side effects are going to last? If that is the cause of it.

1 Answer

Most Helpful Answer

Dr. Strydom, DVM

Answered By Dr. Strydom, DVM

Veterinarian

Published on October 27th, 2019

No, that does not sound normal. At regular/normal dosing Milbemycin is pretty safe and side effects are pretty rare. What you are describing does not sound spot on with side effects for this drug. Side effects are usually neurological. I suggest you get a second opinion from another vet.

( https://www.petplace.com/article/drug-library/drug-library/library/milbemycin-oxime-interceptor-for-dogs-and-cats/ )
Vote Icon1Pet Parents found this answer helpful

Smart Picks for Smart Questions

Have A Vet Question?

Book an appointment with the pros – our expert vets are here to help.

Share

Styled arrow button