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Updated on September 23rd, 2025
Pet's info: Dog | Mixed Breed | Male | unneutered | 15 lbs
I have a rescue organization. Distemper is common in the areas where I rescue dogs. One of my dogs in foster care has a skin infection and is taking cephalexin. However, because I don't want the puppy to get distemper, I asked my foster to start him on his multi-vaccines. Is the cephalexin going to interfere with the effectiveness of the multi-vaccines? (And, yes, he will need a leg amputation.)
2 Answers

Answered By Tomasz Wnuk
Veterinarian
Published on April 16th, 2021
Answered By Tomasz Wnuk
Veterinarian
Hello and thank you for contacting Petco Pet Education Center, formerly Petcoach. It is not an easy situation and we need to take into account how well (or unwell) the puppy is and what is the risk of getting distemper.
If Milo remains in good spirit and has normal appetite and good energy level despite the problem with the right front leg AND there is a high risk of getting distemper, vaccination can be justified and should be effective. I would recommend using a vaccine that contains only distemper and parvovirus.
In other situations, I would suggest to wait with the vaccination until Milo is back in full heath.
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