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Is it safe to give my dog Benadryl if he's on Rimadyl for anxiety?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed | Male | neutered | 100 lbs

Hello. My dog is taking Rimadyl for knee surgery and is freaking out over fireworks. He is 100 pounds and I just have him 100mg Benadryl. He is out and calm now but I just realized it might be bad to mix the meds. Help please. Chris

1 Answer

Most Helpful Answer

Penelope Graben, DVM

Answered By Penelope Graben, DVM

Veterinarian

Published on July 4th, 2018

Hi there,
Rest easy, it is absolutely safe to mix Benadryl and Rimadyl.
In the future, a drug called Trazodone may help him more with the noise phobia.
I hope this is helpful! Thanks for using Petco Pet Education Center, formerly Petcoach!
Vote Icon1Pet Parents found this answer helpful

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