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My dog had surgery. Can I give Benadryl with other meds for licking?

Updated on September 23rd, 2025

Pet's info: Dog | English Mastiff | Female | spayed | 2 years and 4 months old | 150 lbs

Lina had a interdigital soft tissue mass removed Friday. We have both a donut and a soft cone. She gets distraught in the cone and moves so much that it made her foot bleed a little. She tolerates the donut but in certain positions she can still lick her paw. I just gave her rx nutri calm. Can I also give Benadryl? She already takes clorpheneramine for allergies and she took it at 8:00 pm...so wasn’t sure about more antihistamines.

1 Answer

Most Helpful Answer

Jenna Beyer, DVM, MBA, cVMA

Answered By Jenna Beyer, DVM, MBA, cVMA

Veterinarian, Certified Veterinary Acupuncturist

Published on October 11th, 2020

Benadryl doesn’t usually make dogs very sleepy, but you could try it. I would do your best to keep the paw covered or have her wear the cone while you give her lots of reassurance. It can take a few days for them to adapt to the change in sight and hearing while wearing the cone, but after that they should go on like normal. I would also talk to your vet about other sedative options to be used as needed.
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