My diabetic dog is breathing heavily and wheezing. What can I do?

25 ml is an incredibly large dose of insulin, and I’m assuming you mean 25 units. if she’s eating normally and she is prescribed to receive insulin now, you should give it at the prescribed dose. I’m not sure how the spinal problem was diagnosed but Tramadol May help with any pain associated with that, so again, if this is a prescription given by her doctor I would go ahead and give that medication. Panting can definitely be a sign of pain, so I would use pain medications that have been prescribed for her and see if she improves. You should also also ask your veterinarian about whether gabapentin might be a good pain medication for her, as it frequently helps with pain that is neurologic in origin. if she does not improve after receiving her medications I’d recommend seeking emergency care, as difficulty breathing may be the sign of a serious and new problem for her.