Female cat straining, bleeding, pain, and vaginal bulge. What's wrong?

This sounds like she may be in labour if she has not been neutered and requires urgent veterinary attention at this stage - an emergency c-section may be required. Other possibilities may be severe infection or prolapse which would also require treatment urgently before major blod loss

Have her seen by your veterinarian. You can request conservative treatment and your veterinarian may prescribe a broad spectrum antibiotic for a presumed urinary tract infection without performing recommended diagnostics (urine culture, urinalysis, abdominal xrays, blood work). It may help, however the risk is that the bloody urine may not be caused by "simple" infection. Other possibilities are inflammation, tumor or stones. If Luna should become completely obstructed, this will turn into an emergency and potentially life threatening condition.

Vaginal bleeding in a non-cycling female is considered abnormal. If your cat is acting fine otherwise and does not appear to be in distress, this may be something that can wait until tomorrow. However, if you feel the vaginal bleeding is excessive (versus just a red discharge) enough to where blood loss is a true consideration, this is not something that should wait until morning. Hope this helps.

I'm concerned that Deku could have a pyometra. This is an infection of the uterus, and it is fatal without treatment. She has to see a vet now. Please take her into an ER vet clinic; if there isn't one in your area, there will be a vet on call for emergencies. The information to reach that vet is found on a clinic's answering machine or website.

Poor Calliope! It sounds as though she has been through quite a bit recently. As a female cat, it would be highly unusual for her to develop a urinary tract obstruction, whereas it would be more expected in a male cat showing similar signs. As I'm sure you're aware, common causes of blood in the urine in female cats include urinary tract infection and bladder stones. In Calliope's case, a UTI has been ruled out and the chance of having bladder stones is quite low. However, there are a few types of bladder stones that are not visible on x-rays, but these are uncommon. At this point, it may be worth discussing an ultrasound of her bladder with your vet, as the types of bladder stones not typically visible on x-ray can often be seen on ultrasound. Since she is dragging her hind end, it also may be worth asking her vet to check her anal glands to see if these are causing additional irritation. A consultation with a specialist in veterinary internal medicine could also be considered. I hope this helps and that all goes well!

Please take her to your nearest vet if labour does not progress within the next hour. What she has passed may be a deformed kitten but now that she has started the rest of the litter must follow or she is at severe risk of infection

Thank you for contacting Petco Pet Education Center, formerly Petcoach with your question about Luna. Poor girl! That is quite swollen and the area look really wet, so I suspect there is discharge. I'm wondering if she could have a malignant growth that has ulcerated causing this or if it could be a problem with her anal sacs. Her anal sacs may have been impacted and have now ruptured. Without seeing her in person, I ca't say what is going on for sure. I think it's best you take her into a vet immediately to get this diagnosed and treated. I hope this helps!