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When can I apply Revolution to my cats after Advantage 2 flea treatment?

Updated on September 23rd, 2025

Pet's info: Cat | Maine Coon | Male | neutered | 5 months and 9 days old | 5 lbs

We treated our 2 cats with a generic Advantage 2 a week ago. We just received our Revolution in the mail. How soon can we apply the Revolution for their flea infestation? They're 5lbs, and 6lbs. 5 mos old.

3 Answers

Most Helpful Answer

Dr. Melanie, BVSc MS

Answered By Dr. Melanie, BVSc MS

Veterinarian

Published on October 10th, 2017

Great question! According to the package insert for Advantage 2, you can safely reapply once every two weeks, so it would be fine to give them the Revolution now. You can also give them Capstar. It's a one time pill that starts killing fleas in 30 minutes and is safe to give with the Revolution. Don't forget you will need to disinfect the environment as well. Wash their bedding in hot soapy water, and vacuum the furniture and carpet surfaces. You can use a spray to kill fleas in the house, such as Indorex, or a flea bomb would work well to kill the fleas in the home. I hope this helps!
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Related Answers from Veterinarians

  • Answered By Dr. Melanie, BVSc MS

    Veterinarian

    Published on January 15th, 2017

    Revolution will start working 12 hours after application, but it will take 24 hours before all the fleas are killed. As long as your cats have flea protection as well, the fleas will not affect them. You can also give your cats and the stray cat Capstar. It's a one time pill that starts killing fleas in 30 minutes, and it's safe to use now. If he doesn't have a home, you may have a new member of your family :-)

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    1Pet Parents found this answer helpful

  • Answered By Dr. Melanie, BVSc MS

    Veterinarian

    Published on June 24th, 2018

    It's safe to give Chester Capstar. This is a one time pill that starts killing fleas in 30 minutes. Wait until it's been at least two weeks since he last was treated with Revolution, and then it's safe to give him a repeat application of it. Best of luck, I hope this helps!

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    1Pet Parents found this answer helpful

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