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My cat meows nightly. Are cat sedatives like Chlorpheniramine safe?

Updated on September 23rd, 2025

Pet's info: Cat | Domestic Longhair | Female | 4 years and 7 months old | 15 lbs

Misty hollers every night all night and keeps me awake. I have tried ignoring and also feliaway which doesnt work. My vet prescribed Chlorphenirimine a anthestimine for sedation today. Read online that a side effect on cats is inability to urinate which worries me. Is this safe? Also read that the herb Valerian works . What are your thoughts and any other sedative work and is safe? Thank you.

1 Answer

Most Helpful Answer

Lauren Barry, BVSc, MRCVS, DVM

Answered By Lauren Barry, BVSc, MRCVS, DVM

Veterinarian

Published on November 3rd, 2017

My first thought is whether Misty has been spayed/ fixed or not as she may be hollering for a mate.
If she is spayed, then other sedatives / anxiety medicines may be effective to help curb her night time behavior. I dont have a lot of personal experience using chlorpheniramine in cats, but this class of antihisthamine is relatively safe.
The drugs that I may consider dispensing would be gabapentin or amitryptilline. These are both prescription medicines.
I have found minimal benefit in herbal remedies in cats - valerian would not be very effective.
Royal Canin make a diet called "Calm" which can help with anxiety/ stress behaviors as well.
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