My cat is lethargic and staggering after amitriptyline. Is it an overdose?

Was this increase something that your Vet suggested? If not I would absolutely drop the dose back down to what was prescribed. Giving too much can be dangerous. Always consult your vet before changing any medication doses. If your cat gets worse you should go to an emergency vet right away.

0.125mg/lb (0.25mg/kg approx) is the recommended upper dose so some severe and possibly life threatening sedation could potentially occur. I would recommend getting them to an emergency vet for supportive treatment and monitoring until they can clear the drug out of their system; iv fluids, maintaining body temperature and possibly the administration of an antidote may be required

Mirtazapine does have a side effect of drowsiness or sedation in pets. It is commonly used in cats as an appetite stimulant. 30mg would be 4 times higher than I normally use, and this overdosage can cause: 57% vocalizing, 38% agitated, 23% vomiting, 21% tachycardic, 15% ataxic and 11% lethargic. The symptoms can last a little longer than 72 hours. As long as Dolly is still eating and drinking normally, I would continue to watch her. If the she is still not completely normal in a day or two, she may need a checkup with a vet.

I'm sorry to hear Holly ate something she shouldn't! It's good to know she is responsive. I would strongly recommend contacting the Pet Poison Helpline for further information about this medication and to determine if the amount she ingested is cause for concern. She is a very small little dog. If they advise that toxicity is possible at this dose they will provide you with a case number that you can give to your veterinarian. Your vet can then call the helpline themselves and they will be advised if any treatments and antidotes that need to be administered. Holly make need to stay in the hospital, and receive IV fluids and activated charcoal. Your vet may also recommend some baseline bloodwork and this may need to be monitored in the future. Good luck-I hope Holly improves soon!

This is about a 5-fold overdose for your cat. Please take her to your vet right away. He will have to make your cat regurgitate the capsule. At overdose with 20 mg/kg Clomicalm (5 times the maximum therapeutic dose), bradycardia and arrhythmias (atrioventricular node block and ventricular escape beats) were observed approximately 12 hours after dosing in dogs. Cats are usually more sensitive to medications, so this may be more toxic. Please take your kitty to your vet now.

Alone, these drugs would not be too concerning for a 2x overdose, but the combination is more dangerous to overdose. The combination can cause significant problems with the neurotransmitters in the brain and lead to life-threatening heart problems, breathing problems and seizures. This is not a big overdose, so I can't say that these problems will occur, but it is definitely possible. For this reason, it's best to take him to a vet right away. The vet can take steps to keep the medication from being absorbed and give the necessary medication to keep Oscar safe from potential adverse effects. I hope that helps and all is well with Oscar.

Unfortunately, this could be serious. As I'm sure you know, this is an extended release product, and the typical dose is 100mg per cat every 24 hours, so yes, I believe you very well might see toxicity from this, including (on the mild side) excitement, hyperactivity, vomiting, and diarrhea, all the way up to seizures. You have a couple of options: you can call the ASPCA's toxin hotline at (888) 426-4435; they will charge you for the call ($45) but they keep an extensive database on all types of overdoses and will be able to tell you if this is a significant overdose. Your other option is to take Nox to an emergency clinic now to have vomiting induced, and have him treated for the ingestion. They will be able to administer activated charcoal to absorb any residual toxins in the gut as well.