Why is my cat's Depo-Medrol asthma shot wearing off so quickly?

There is an injection called depo medrol, i personally do not recommend it as potential side effects can be very serious. the better option in my opinion are tablets, prednisolone tablets for cats are very small and easily hidden in gravy or wet food. most cats eat the wet food and never even suspect there is a tablet inside. it's not a big deal if you are 1-2 hours late.

If the depo medrol works, then this is likely feline asthma. Unfortunately the treatment for that is generally a gluco-corticoid, but usually as an inhaler (with fluticasone) and a broncho-dilating medication to open the airways and facilitate breathing.. There have been various treatments with other anti-asthma medications such as zaphirlucast and montelucast, however they are not licensed for cats. Here is some really good relevant information: http://www.vet.cornell.edu/FHC/health_information/Asthma.cfm

Poor Maggie. I think there has been a misunderstanding. They probably gave 20mg (milligrams) which is equal to either 0.5mL (milliliters) or 1.0mL of depo-medrol depending on the concentration your vet carries. The general dose that most vets use is 20mg depomedrol per cat every 8 weeks as needed. I seriously doubt anyone would give 20mL of this drug. Also, it could be wearing off quicker if there are more allergens causing her skin to act up. With it being the changing of the seasons, this very well could be the issue. Also make sure she is on a high quality flea preventative. One flea bite can cause a major allergic reactions in cats with her problem. If she needs another depomedrol shot, I would talk to your vet and see if they would be willing to repeat the injection as early as 6-8 weeks during high allergy season. You could also start giving her benadryl twice a day. See link below. I hope this helps! https://www.petcoach.co/canigive/cat/benadryl/#!

You will have to have the prescription sent to your vet for approval and it would be a good thing to talk with them about how to give it and how much it has taken in the past to keep the sign ms controlled since the dose can vary. I would be cautious if this plan long term since he is so young. This is a strong steroid that becomes less effective the more you give it and can have side effects such as diabetes, liver or kidney damage or heart failure in cats. I would look into other treatments for your allergies such a diet change or Apoquel daily

Thanks for the additional information! Depo-Medrol is a long-acting steroid that is often used as a symptomatic treatment for itchy skin problems in cats - if Taira has allergies or some other type of chronic skin issue, the Depo-Medrol will not cure the problem, but only relieve her symptoms for a few weeks. If the itching recurs once the steroid wears off (usually 4-6 weeks in cats), you may want to talk with your vet about options for diagnosing the skin problem and getting her started on a better long-term treatment plan. Based on these lab results, I do not see any reason for the liver supplement - I would suggest giving your vet a call to clarify this since you have some concerns about it. He/she should be able to explain why it was prescribed.

There are different types of steroid shots. Long term use or high doses can affect their liver or kidneys. There has been studies that some forms can bring on a form of heart failure if already underlying with it. The do make asthma inhalers for cats that may be easier to give. If she is not eating I would have her rechecked to have blood work done and see what else is going on

Absolutely not, Depo is very unsafe long term, it can cause diabetes and other severe non reversible conditions. I would recommend switching treatment to either low dosage oral daily prednisolone or Cyclosporin, both should have the same effect on the condition with much less potential side effects.