Trifexis Dog Medicine and Prescriptions

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Health & Wellbeing
Simparica Trio vs. Trifexis: Best Flea & Tick Med for Your Dog?
Unsure which flea & tick medication to choose for your pup? Check out our comparison of Simparica Trio vs. Trifexis to see which product will work best for your dog!
Updated on October 29th, 2025
Health & Wellbeing
Interceptor vs. Heartgard: Guide to Heartworm & Worm Prevention
Search Petco to find the benefits of both Interceptor and Heartgard worm medicines for dogs. We strive to help you keep your pup happy and healthy.
Updated on October 29th, 2025
Health & Wellbeing
Interceptor vs. Interceptor Plus: Best Heartworm & Worm Med for Dogs
At Petco, learn more about the benefits & differences of Interceptor & Interceptor Plus dewormer for dogs with heartworm, roundworms, hookworms & tapeworms.
Updated on October 29th, 2025
Health & Wellbeing
Enalapril for Pets: Treat Heart, Kidney & Blood Pressure Effectively
Do you think your dog or cat has heart issues and high blood pressure? Visit Petco to learn how enalapril can help your pet.
Updated on October 29th, 2025
Health & Wellbeing
Clavamox for Dogs & Cats: Treat Infections & Keep Pets Healthy
Do you think your pet has a bacterial infection? Visit Petco to learn how Clavamox can help your dog and cat.
Updated on October 29th, 2025
Health & Wellbeing
Is Triflex a generic version of flea and tick medicine? My grandma said she used it, but I think she meant Trifexis. I just want to be sure.
Hi, thanks for using Boop by Petco! So there is something called Triflex which is a human joint supplement. It isn't used for flea and ticks. I would ask her again and ask her what she uses the product for. If she is referring to flea and tick prevention she likely just misspoke as there is no generic for Trifexis that I am aware of. Have a good day!
Updated on August 12th, 2025
Health & Wellbeing
My 2 small dogs have been Trifexis for the past 1 to 2 years but last month it stopped working & they're covered in fleas! What should I switch to?
Oh no! Fleas are not a fun surprise! Trifexis prevents fleas, heartworms and some intestinal parasites. Since this isn't working for you, I typically recommend using either Nexgard, Bravecto or K9 Advantix II as flea and tick prevention. Please note that Nexgard and Bravecto are prescription-based (like the Trifexis), so these would need to be obtained by Prince's vet. Prince and his friend will also need to start a separate heartworm prevention, such as Heartgard or Interceptor, but again, these are prescription-based. Until you can pick up these new medications, you can bathe both dogs in original blue Dawn dish soap because this will help to kill the existing adult fleas. I hope this helps and that all goes well!
Updated on August 12th, 2025
Health & Wellbeing
Can I give my puppy Trifexis and a dewormer/Febendazole at the same time?
Hello and thank you for reaching out to Boop by Petco. Yes, these medications are safe to give together. I recommend offering a small meal or treat beforehand so that there is a little food in her stomach before getting these medications. She can also get a small tasty treat afterward so she knows she a good girl! I hope this is helpful - she is VERY cute!
Updated on August 12th, 2025
Health & Wellbeing
Snowball only has peanut butter once a month when it’s time to take her trifexis. We give her Skippy. Would it be safe to give it to her in skippy pretzel bites? Or should I just stick to the plain peanut butter.
Pretzel bites are ok as well. Either is fine in this case. : ) Trifexis isn't the best smelling flea/heartworm preventative, so I understand the struggle with trying to make it more palatable for her. Best wishes with your pet Snowball moving forward! Take care.
Updated on August 12th, 2025
Health & Wellbeing
If I give my puppy TriFexis for the various worms and fleas, can I comebine it with anything to protect against ticks as well? TriFexis doesn’t cover ticks. I prefer an oral treatment versus topical or collars. Any recommendations? I can also swap ou
It is generally not recommended to use two oral products together. It's not to say it's impossible but many of these companies have not done the testing to know if there are interactions. You may discuss this with your regular vet to see if they have any experience with this. Most topical flea and tick products are expected to be safe to use with Trifexis. There is also a collar called a Preventic which is fine to use with oral products. Most people only put the collar on the pet when it is going out to tick areas and they remove it when the pet is not in those areas. Another option is to ask your vet if they would exchange the product for something like Simparica and Interceptor which would get all your parasite concerns. Some clients will also switch products when ticks are in season or when exposure is expected and then switch back once the exposure time is over. I hope this is helpful and please feel free to post any additional questions.
Updated on August 12th, 2025