Health & WellnessMy dog has fleas on Nexgard. Can I use Advantage II topical now?
Thank you for contacting Petco Pet Education Center, formerly Petcoach with your question about Knuckles. It's not recommended to mix flea treatments together. I would wait one more week, then give the Advantage II. Until then, you can give him Capstar. It's a one time pill that starts killing fleas in 30 minutes, and it's safe to give now. You can give him one a day until you can apply the Advantage II. You will also have to disinfect the environment. Wash his bedding in hot soapy water, and vacuum the furniture and carpet surfaces. You can use a spray to kill fleas in the house, such as Indorex, or a flea bomb would work well to kill the fleas in the home. I hope this helps!
Updated on September 24th, 2025