Is it safe to stop prednisone cold turkey for my dog with cancer?

Thank you for contacting Petco Pet Education Center, formerly Petcoach with your question about Dozer. I'm sorry he has cancer! Do not suddenly take him off the steroids, you should work with the local vet to taper him off of them if you do not want him to be on them. Give them a call to discuss a schedule to taper them off. I hope this helps!

Your dog should be weaned off Prednisone slowly. In many ways, prednisone is similar to the corticosteroid hormones cortisol and aldosterone produced by the adrenal glands located along each kidney. Because of this, when taking prednisone, the adrenal glands start decreasing their production of cortisol. It would be too shocking for the adrenal glands to find themselves out of the blue in need of producing cortisol in large amounts again, so by tapering the prednisone gradually, the glands are given some time to resume their normal function. The main risk is what is called an " addisonian crisis" or "iatrogenic hypoadrenocorticism" which can be life threatening and can cause the dog to go into shock. This can happen when the prednisone is stopped out of the blue and the adrenal glands are dormant because they weren't given a chance to gradually become active again. When this happens, the dog's potassium and sodium levels get unbalanced. The sodium levels start to fall, while the potassium levels start to rise. High potassium levels can have a detrimental effect on the heart and can lead to circulatory collapse. Affected dogs may appear weak, lethargic, they may vomit, have a low, irregular heart rate and may go into shock and even collapse. Affected dogs need to seek immediate emergency treatment to correct the electrolyte imbalances and possible low glucose levels through supportive care consisting of fluid therapy and careful monitoring. Rapidly-acting corticosteroid medications such as prednisolone sodium succinate or dexamethasone sodium phosphate may be needed. This whole ordeal can be easily prevented by gradually tapering the dog off the steroids. Dogs on prednisone for quite some time, need to be tapered even more gradually. The vet will tell owners how.

Is there a reason you want to stop the prednisone? I would recommend not stopping it and if you feel it is better to stop the prednisone then I would recommend weaning off of the prednisone. I would discuss how to wean the prednisone with your veterinarian. Thank you for using Petco Pet Education Center.

Thanks for using Petco Pet Education Center, formerly Petcoach! I am sorry to hear Diesel isn’t feeling well. The prednisone is supposed to help slow the growth of the cancer but eventually it won’t be effective. Prednisone alone isn’t enough to cure him. If he is getting worse and the lymph nodes are growing it is likely the prednisone is no longer helping. I would discuss your options with the vet that diagnosed him but there isn’t much more they can do for him. I am so sorry and I hope the rest of his life is pain free. Good luck and kisses to Diesel!

Max is already on a high dose of prednisone and I doubt increasing the dose would improve his symptoms. Prognosis depends on the type and stage of lymphoma, but in general the median survival time with prednisone is about a month. I'm so sorry about Max's diagnosis.

I'm sorry to hear that Daisy received this diagnosis. There are certainly risks and benefits to both options with respect to side effects, life span and cost. Side effects of prednisone in the short term can cause excessive drinking and urination. Some animals with underlying heart disease can go into congestive heart failure and other animals can develop diabetes as a result of the high doses of corticosteroids given in these situations. Around 40% of dogs can achieve remission for 4-6 weeks with prednisone alone, but this is certainly based upon an individual's response to medication and if any metastatic (spread) of disease is present. Obviously, this treatment is much less expensive, but a much shorter survival time is expected. Daisy's chemotherapy protocol is based on whether she has B cell or T cell lymphoma and if any metastatic disease is present. As a generalized statement, lymphoma responds to chemotherapy better than most cancers. Oncologists strive to administer chemotherapeutic drugs at doses that will kill cancerous cells while avoiding as many side effects as possible. The side effects possible vary with different chemotherapeutic drugs. In short, there is no right or wrong choice. You need to evaluate both options to determine your comfort level. If you haven't already done so, consider a consultation with a veterinary oncologist for more information. I hope this helps!

I believe I provided you with the answer to this question before regarding the tapering. Now that I know that he is being treated for MCT, I would recommend speaking to your vet regarding the treatment. Prednisone is not generally considering the gold standard treatment for this condition. If he has not offered you a referral to an oncologist, I would request one if you are looking to pursue any other therapies. One of the best therapies available right now for Mast Cell Tumors is a drug called Palladia. I would love to consult with you concerning Hachi's condition including this drug and a possible tapering schedule if you were not clear on the answer I provided you earlier. Just let me know or one of the other experts here so we can try and find a way to make Hachi more comfortable.