Should I worry about my puppy's painless lump after parvo shots?

I wouldn't worry about the lump just yet, but I would have it checked out by the vet on Monday. This lump could be a cyst, an abscess, a lipoma, or a benign tumor. Any suspicious lumps should be examined by the vet. The vet can perform a test called a fine needle aspirate on it. To do this, the vet sticks a small needle into the lump to get a sample of it's cells, and examines the cells on a slide under a microscope. It's usually painless to the animal, and relatively quick to perform. Once the vet diagnoses the cause of the lump, they can discuss treatment with you.

It is possible that Trixie is having some inflammation associated with the shot she was given. This inflammation may take several months to resolve. If you are very worried you can take her to the vet, where they may be able to look at some of the cells present in the lump. Otherwise, you can monitor at home. If the lump does not resolve in a month or two, I recommend bringing her to the vet at that time.

Poor Rocky. A lump at the vaccination site, as well as some soreness and tiredness, are normal after getting a vaccine. If Rocky will let you, you can try holding a warm compress (such as a washcloth soaked in warm water and then wrung out) against the sore area for a few minutes 1-2 times daily until he seems to be feeling better. Usually, most pups are back to normal within a few days :)

Many injections can cause temporary lumps which are generally painless and resolve over 4-6weeks. If there is any discomfort or heat in the area or it does not reduce over time you should have it checked by your vet to rule out more sinister causes

Try not to worry, but I would make Buttecup an appointment at the vet. The lesion could be an infection and they can treat it, or if it is a lump they can test it to see what it is. If you want to wait a while you could try salt bathing it then if it's not improving attend the vet.

That is a very common occurrence after vaccination. The vaccine can cause a localized reaction and it should resolve on its own within a month. If it persists, seems larger, or bothers him that have your vet take a look at it.

DHPP vaccines should be given every 3-4 weeks until the last shot on or after the 16 week birthday. Rabies is only given once, typically around 12 weeks of age. I do not use the corona vaccine. Kennel cough is given once or twice depending on the manufacturer's guidelines. I deworm my puppies at each vaccination appointment and then annually. All vaccines should be boostered at 1 year of age. Any injection can cause a local reaction, it should not drain and it should not be painful. Other possible causes of a lump include abscess or an enlarged lymph node. You can have your vet check on this at the next appointment (or sooner if Oreo isn't feeling well).