My Yorkie won't eat, drink, or play. Vet tests are clear. What's next?

I am so sorry to hear about your poor yorkie. First, I want to applaud you for allowing the veterinarian to perform diagnostic testing in the form of x-rays and bloodwork. This is a great first step and can provide them with a baseline in case they need to do further testing in the future.

Unfortunately, there are still so many diseases or conditions that a dog can get that will not show up on an x-ray or routine bloodwork. For example, gastrointestinal diseases like inflammatory bowel disease do not show up positive with only x-rays and routine bloodwork. Another example is if your dog is In pain for some reason such as a muscle pull or they hurt their back while jumping on the couch, etc. pain can cause a dog to exhibit all of the clinical signs that your dog is showing such as not eating, not drinking, and not playing at all. And pain cannot be diagnosed in x-rays or bloodwork. The point being that there are so many different diseases and ailments that a yorkie can get that just won’t show up with routine testing and may need specialized further testing modalities.

My advice is the following: if he is not showing signs of improvement within 24 hours, please take him back to the veterinarian to do further testing or even start IV fluid’s and other supportive treatments. If he is getting better, I would still call the veterinarian and give them an update on the condition to see if they want to recommend anything else you can do to help him at home. I hope this helps.