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Anaphylactic reaction to puppy vaccine. How to vaccinate safely?

Updated on September 23rd, 2025

Pet's info: Dog | Goldendoodle | Female | unspayed | 2 months and 26 days old | 14 lbs

My 11 week old Goldendoodle had an anaphylactic reaction to her DHPP vaccine. What should be do about vaccines in the future? All of my vets are saying no to future vaccinations. She nearly died and they said it could be fatal if I did it again.

1 Answer

Most Helpful Answer

Linda G,  MS, DVM

Answered By Linda G, MS, DVM

Veterinarian

Published on February 12th, 2018

Hello. This is a problem in some dogs. I would recommend discussing with your vet the possibility of bringing Nyla to the office on the morning of her next vaccination. Have them give a steroid injection called Dex SP and an injection of diphenhydramine & let them keep her all day. She may do OK with just this one booster vaccine. In a month, I would repeat this before giving rabies. In a year, do the same precautions & repeat rabies & distemper vaccines, again 1 month apart. Then, hopefully, all she will need is a rabies vaccination once every 3 years. Thanks for using Petco Pet Education Center, formerly Petcoach.
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