Is it safe for my dog to take trilostane and turmeric together?

Hello and thank you for contacting Petco Pet Education Center, formerly Petcoach. I will strongly discourage you from giving Sophia Trilostan without knowing for sure that she has Cushing disease. She may have, for example ascites, diabetes or internal organ enlargement, which makes the belly look potted. In that case, giving Trilostan can lead to a life-threatening hypoadrenal crisis. Please, take your dog to your local vets to confirm the diagnosis and then start the treatment, if necessary.

Cushing's is a disease characterized by an excess of cortisol, and prednisone is a corticosteroid that acts like cortisol in the body. So if a dog is taking prednisone for a medical condition herbs to treat Cushing's would potentially counteract the prednisone, and I wouldn't recommend them.

It's never a good idea to stop or make any dosing changes in a prescription medication without your vet's input, so I would definitely recommend giving him/her a call to discuss your concerns before you change anything. In general, I can tell you that if your dog has symptoms like lethargy, vomiting or diarrhea, or not wanting to eat, this may be a sign that the trilostane dose needs to be reduced. So this is definitely cause for concern - I would call your vet today to let them know. They may recommend having Max come in for blood work to check his cortisol levels - this will help determine what needs to be done regarding his medication.

I would not stop the benazepril. Unfortunately there is no scientific proof tumeric works, and leaving Lucy's CHF untreated would be awful for her. You can give it to her in addition to the benazepril.

Vetoryl (trilostane) is the best medication for managing Cushing's disease, but I'm sorry to hear that Lacy has not been tolerating it well. I have anecdotally heard of some vets using a variety of supplements for managing Cushing's disease signs, but these supplements will not ultimately decrease the cortisol production by the adrenal glands and generally seem ineffective. I don't know how long Lacy was receiving Vetoryl, but some dogs can initially become lethargic, vomit, have diarrhea, or a decreased appetite. Fortunately, these signs typically resolve after a few days to a few weeks on the medication. It may be worth discussing a temporary dose adjustment with Lacy's vet to see if she tolerates a lower dose better before gradually increasing to her 30mg dose. Some dogs also benefit from supportive measures (anti nausea medications, bland diets, etc.) in the first few days to weeks of treatment. I hope this helps and that all goes well!

Typically Cushing disease does not cause seizure like behavior. Also I have used trilostane often and have never seen seizures with the medicine. With a very old dog it is possible that Emma has started having seizures secondary to his age/brain function. I would recommend consulting you vet about possible a referral to a neurologist or even starting seizure medications if needed. You can try and video tape the episodes to help your vet determine what is actually going on. Hope that helps

Yes, that is true. The FDA says the medication should not be used in dog's with liver disease. That being said, elevated liver numbers (depending on how high they are) may not indicate liver disease, and it may be ok for Oscar to have Vetoryl. I would speak to his vet about your concerns.