Is Vetoryl safe for dogs with Cushing's and elevated liver numbers?

Vetoryl (trilostane) is the best medication for managing Cushing's disease, but I'm sorry to hear that Lacy has not been tolerating it well. I have anecdotally heard of some vets using a variety of supplements for managing Cushing's disease signs, but these supplements will not ultimately decrease the cortisol production by the adrenal glands and generally seem ineffective. I don't know how long Lacy was receiving Vetoryl, but some dogs can initially become lethargic, vomit, have diarrhea, or a decreased appetite. Fortunately, these signs typically resolve after a few days to a few weeks on the medication. It may be worth discussing a temporary dose adjustment with Lacy's vet to see if she tolerates a lower dose better before gradually increasing to her 30mg dose. Some dogs also benefit from supportive measures (anti nausea medications, bland diets, etc.) in the first few days to weeks of treatment. I hope this helps and that all goes well!

Generally yes. Always make sure to discuss any concerns with your veterinarian regarding procedures or medications. Your veterinarian is an excellent resource for information and can help guide you in the decision making process. I hope this helps and please feel free to post any additional questions.

Hello. Yes, as long as the clinical signs of Cushing's are not hindering you or your pets' life. Vetoryl will control most of the symptoms associated with Cushing's by decreasing the influence of cortisol on the body, so as long as your pet seems happy & comfortable, the choice to use this medication is yours. Thanks for using Petco Pet Education Center, formerly Petcoach.

Hello. For the most part, Vetoryl is used to control the symptoms of Cushing's by controlling the production of glucocorticoids. Overproduction of glucocorticoids is responsible for the symptoms of excessive drinking & urination but does nothing for the actual tumor growing on his pituitary gland. If Izzy's symptoms are manageable & tolerable then medication is not necessary. This would be your choice. But if his symptoms do get worse, at least consider once a day dosing. Most dogs do very well on twice daily dosing, but once a day can help in many pets. Thanks for using Petco Pet Education Center, formerly Petcoach.

Great catch on your part! You obviously are doing a great job taking care of Schnoodle! Your vet probably is aware of this potential interaction but decided the benefits of starting her on Vetoryl outweigh the risks. However, I would definitely mention it to the vet when you stop by to pick up the meds. Your vet will likely require routine lab work to monitor Schnoodle's electrolytes (which includes potassium) as well as her renal and kidney function.

Hello and thank you for your post! I am sorry to hear that Aprile is not feeling well. With the Cushing's medication, this can cause the reverse disease called Addison's disease. The Cushing's medication will decrease the steroids in the body. Sometimes this medication can decrease the steroids too much and lead to an addisonian crisis. If your vet has not checked blood work to see what the electrolytes and the rest of the blood work looks like I would certainly want to see what the CBC and chemistry look like. If your vet has examined her and deems that steroids are necessary due to the examination and clinical appearance then a dose of steroids is probably okay to administer with the suspicion that the Cushing's medication has decreased the natural steroids in the body too much. Famotidine is just Pepcid AC, so it is absolutely safe to give. If the pancreatitis is very bad, then I would suggest keeping her in the hospital on supportive care until she's feeling better. I hope this helps and that she gets better! Please let me know if you have any other questions or concerns. I'm also available via phone or text consultation.

Hi, thanks for using Petco Pet Education Center, formerly Petcoach! Oh no! Poor Charlie! I have not heard of strokes being a side effect of Vetoryl (trilostane). It is very well tolerated and has significantly decreased the side effects for treating cushings compared to the older drug choice. Untreated cushings can cause clots though. I wonder if the stroke is unrelated and maybe he is experiencing a Vestibular event. Look at his eyes and see if they are moving abnormally. Dogs with Vestibular disease have abnormal eye movements, a head tilt, fall to one side, walk drunk, pant and drool because they are very dizzy. Vestibular disease is rarely fatal and can be managed. They tend to get better. I would encourage you to take Charlie to an emergency hospital to be evaluated. I wish you the best!