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My dog has swollen toes and inflamed eyes. Is it allergies or pemphigus?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Male | neutered | 48 lbs

My dog has a blister on her toe which she licks constantly. Now she has blister between her toes. One digit is extremely swollen. Cellulitis? Also for the last two weeks she has been rubbing her face by her eyes on her paw. The skin around her eyes is inflammed. Could this be pemphigus ?

1 Answer

Most Helpful Answer

Lauren Barry, BVSc, MRCVS, DVM

Answered By Lauren Barry, BVSc, MRCVS, DVM

Veterinarian

Published on July 16th, 2017

Hopefully Daisy has a less serious illness than pemphigus - typically we see interdigital cysts (blisters between toes) and sometimes blepharodermatitis (eyelid swelling) as symptoms of general allergic skin disease. Pemphigus is diagnosed with skin biopsies (taken surgically). I expect your vet may suggest a trial of an anti-allergy medicine like apoquel or possibly steroids to see if the problem resolves before a biopsy is needed. The vet may also suggest a food trial, and also other measures to control allergens.
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