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My dog has itchy bumps after ivermectin for demodex. Is it hives?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Male | neutered | 7 months and 11 days old | 28 lbs

Diagnosis of demodex on 4/2/18, received ivermectin injection #1. Skin broke out in hives on 4/7, resolved within 3 days with Benadryl BID. 4/13 Ivermectin #2 injection. 4/16 came home to dog covered in possible hives. Dog is itchy, skin is covered in bumps that are starting to develop a crust. I am wondering if this is hives or mange reacting to the ivermectin or something completely unrelated. No changes with diet or environment. Will contact vet tomorrow, but would like second opinion

1 Answer

Most Helpful Answer

Daniel Fonza, DVM

Answered By Daniel Fonza, DVM

Veterinarian

Published on April 16th, 2018

Hi there and thank you for using Petco Pet Education Center, formerly Petcoach to address your concern. Personally, I no longer use Ivermectin to treat Demodex. I stopped about a year ago. I started using Bravecto (flea and tick preventative) that is used to treat Demodex off label. It is not marketed for use in cases of Demodex but many vets, including myself, have been using Bravecto to treat Demodex cases with very fast responses to treatment. I would discuss this as a different treatment option with your veterinarian. Rather than using Ivermectin injections, the Bravecto is given as a treat and lasts for about 3 months for one single dose. I hope this helps! Please let me know if you have any other questions or concerns and I would be more than happy to help you further.
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