Is 25mg Benadryl too much or safe for my 12lb dog's puffy eyes?
Thank you for submitting your question regarding Misha. I typically recommend giving Benadryl at 1mg/pound. So I would give around 12mg orally every 8 hours. The dose you were told is a little high, but probably still reasonable. Antihistamines are a somewhat hit and miss in dogs. They will help some dogs, but not others. If you do not see an improvement in the skin around his eyes, then he will need to see his veterinarian. He could have a food allergy, for example, as this commonly affects skin around the eyes. In these case, the dog may be experiencing vomiting, diarrhea or an increased number of bowel movements per day. These dogs can also have skin issues elsewhere and are prone to ear infections. I hope this information helps!
Updated on September 23rd, 2025