Why is my dog still itching on Apoquel & has bloody diarrhea/lethargy?
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Apoquel will not work if the dog has a skin infection. I recommend anytime that the apoquel has stopped working that the dog be taken to the Vet for an exam to check for a bacterial or yeast infection. Most dogs with allergies need to be on a special diet, apoquel or cytopoint, an antihistamine and an Omega 3 supplement to keep the dog comfortable, but flare ups are bound to happen, we just hope less frequently.
As for the bloody diarrhea, it is likely unrelated to her skin and the apoquel but it is fine that you stopped it. Especially if it wasn't working. The blood indicated inflammation in the colon. Common causes of diarrhea are: intestinal parasites, viral or bacterial infections, dietary indiscretion, pancreatitis, food allergy/intolerance, reaction to a new food/treat/table food.
If the diarrhea is bad I would fast her for 12-24 hours to rest her GI tract then start feeding a bland diet of boiled chicken or hamburger with rice. Feed 1 cup per 20 lbs per day until 2 normal stools.
I wish you the best!
Updated on September 23rd, 2025