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Can I use Advantage II and Seresto collar on my extra large dog together?

Updated on September 23rd, 2025

Pet's info: Dog | Mixed Breed Large (61lb +) | Male | neutered

Can u use advantage II and a seresto collar on extra large dog at same time

1 Answer

Most Helpful Answer

Jennifer Summerfield, DVM CPDT-KA

Answered By Jennifer Summerfield, DVM CPDT-KA

Veterinarian, Certified Dog Trainer

Published on June 18th, 2017

It would not be recommended to do this, as a Seresto collar and Advantage II have the same active ingredients - so you would essentially be giving your dog a double dose of medication, which may not be safe. It shouldn't be necessary to use two different flea control medications as long as you are using an appropriate size/dose for your dog's weight.

If you are already using one of these products and are finding that it is not effective, I would recommend switching to a different flea medication entirely, such as Nexgard or Bravecto - these are both much more effective in my experience.
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